Optimal Prostate Fractionation Study
To compare the toxicity, rate of local control, biochemical failure rate and quality of life of three different radiotherapy techniques (moderate hypofractionation, stereotactic body radiotherapy (SBRT) and standard radiotherapy plus 2 fractions of SBRT (BOOSTER)
• Histologically proven prostate adenocarcinoma
• PSA obtained within three months prior to enrolment
• ECOG performance status 0 to 2
• Ability to understand and the willingness to sign a written consent
• Suitable for high dose irradiation to the prostate
⁃ To be eligible for the arm containing Stereotactic Booster alone approach patient must have the following
• No contraindication to MRI such as pacemaker and severe claustrophobia
• Patient must be able to have fiducial markers placed in the prostate
• Patient must be able to have hydrogel insertion at the same time as fiducial markers
• Must have IPSS less than 15